The Role of Exosome RNA in Cancer

The Relationship Between Exosomes and Cancer Exosomes are nanoscale vesicles derived from intracellular lysosomes that shuttle a variety of biomolecules, such as nucleic acids, proteins, lipids, amino acids and metabolites, and play a key role in regulating intercellular communication. Exosomes can be secreted by almost all types of cells, including immune cells, blood cells, neuronal…

Single-Cell RNA Sequencing in Drug Discovery and Development

What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to…

How to Analysis Glycosylation Sites

Glycosylation represents a ubiquitous post-translational modification mechanism whereby carbohydrate residues are appended to proteins and lipids, thereby exerting substantial influence over their conformational dynamics, molecular stability, and biological functionality. A nuanced comprehension of glycosylation sites assumes paramount importance in unraveling the multifaceted intricacies underlying the biology of glycoproteins and their intricate participation in a spectrum…

What is Glycosylation of A Protein

What is Protein Glycosylation Protein glycosylation denotes the enzymatic coupling of carbohydrate moieties, notably sugars, to predetermined amino acid residues within proteins, thereby yielding glycoproteins. This intricate biochemical phenomenon unfolds within the endoplasmic reticulum and Golgi apparatus, orchestrated by a heterogeneous ensemble of glycosyltransferases. Notably, glycosylation manifests at two primary loci: N-linked glycosylation, wherein glycans…